[Combined use of non-depolarizing muscle relaxants in clinical anesthesiology]. / Kombinirovannoe primenenie nedepoliarizuiushchikh miorelaksantov v klinicheskoi anesteziologii.

Clinical observations in 99 patients and 74 experiments in cats enabled the authors to suggest that nondepolarizing myorelaxants when used in combination affected different portions of cholinergic receptors of the end plate of motor nerves causing greater inhibition of neuromuscular transmission. So an associated simultaneous application of such myorelaxants as tubocurarine and tercuronium as well as tercuronium and Arduan in special sub-blocking doses gives a complete relaxation of skeletal muscles without side effects which allows such methods to be recommended in surgical practice for anesthetic maintenance of operations on high risk patients.