Immunotherapy comes of age: Immune aging & checkpoint inhibitors.
J Geriatr Oncol
; 8(3): 229-235, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28223073
ABSTRACT
Immune checkpoint inhibitors (ICIs) are based on the understanding that there are multilayered checks and balances which can be manipulated to unleash already existing, but paralyzed, immune responses to cancer. These agents are safer and more efficacious than classic cytotoxic drugs making them a very attractive therapeutic option, especially in older adults. Current available data do not suggest significant age-associated differences in the clinical profile of ICIs. It must be noted, however, that there is still relatively little information on the use of ICIs in adults over 75years of age and aging is associated with a decline in the immune system or "immunosenescence" which theoretically can reduce the efficacy of these immune based therapies. In this paper, we review the mechanism of action of ICIs, current clinical data on their use in older adults, and age-associated immune changes that might have a direct impact on their activity in this population. We chose to focus on mainly adaptive cellular immunity, and especially on components of the immune system that are implicated directly in the immune checkpoint process.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Imunoterapia
/
Neoplasias
Limite:
Aged
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Humans
Idioma:
En
Revista:
J Geriatr Oncol
Ano de publicação:
2017
Tipo de documento:
Article