Assessing quality of life in Alzheimer's disease: Implications for clinical trials.
Alzheimers Dement (Amst)
; 6: 82-90, 2017.
Article
em En
| MEDLINE
| ID: mdl-28229126
ABSTRACT
INTRODUCTION:
Characterization of the quality of life (QOL) in Alzheimer's disease (AD) scale within the context of a clinical trial may inform its applicability in future trials.METHODS:
Using data from 1322 patients enrolled in two phase-III studies (EXPEDITION 1 [NCT00905372] and 2 [NCT00904683]) of intravenous solanezumab in outpatients with mild AD dementia, correlations between patient- and caregiver-assessed QOL and between QOL and clinical outcome measures were examined. Longitudinal effects of solanezumab over 80 weeks were explored, controlling for patient and caregiver baseline characteristics.RESULTS:
Caregivers rated patients' QOL worse than did patients themselves. Patients' QOL was correlated, albeit modestly, with clinical/health measures. Patients' QOL changed minimally over 80 weeks, although a treatment effect of solanezumab on QOL was detected.DISCUSSION:
Further investigations are needed to determine the optimal measures with which to quantify and qualify QOL of patients with mild AD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
Aspecto:
Patient_preference
Idioma:
En
Revista:
Alzheimers Dement (Amst)
Ano de publicação:
2017
Tipo de documento:
Article