C-C Bond Migration in the Cycloisomerization of 1,6-Enynes.
Org Chem Front
; 3(10): 1228-1235, 2016 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-28239480
ABSTRACT
A full account of our investigation of C-C bond migration in the cycloisomerization of oxygen-tethered 1,6-enynes is described. Under Pt(II) and/or Ir(I) catalysis, cyclic and acylic alkyl groups were found to undergo 1,2-shifts into metal carbenoid intermediates. Interestingly, this process does not appear to be driven by the release of ring strain, and thus provides access to large carbocyclic frameworks. The beneficial effect of CO on the Pt(II) and Ir(I) catalytic systems is also evaluated.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Chem Front
Ano de publicação:
2016
Tipo de documento:
Article