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Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
Scott, Jack D; DeMong, Duane E; Greshock, Thomas J; Basu, Kallol; Dai, Xing; Harris, Joel; Hruza, Alan; Li, Sarah W; Lin, Sue-Ing; Liu, Hong; Macala, Megan K; Hu, Zhiyong; Mei, Hong; Zhang, Honglu; Walsh, Paul; Poirier, Marc; Shi, Zhi-Cai; Xiao, Li; Agnihotri, Gautam; Baptista, Marco A S; Columbus, John; Fell, Matthew J; Hyde, Lynn A; Kuvelkar, Reshma; Lin, Yinghui; Mirescu, Christian; Morrow, John A; Yin, Zhizhang; Zhang, Xiaoping; Zhou, Xiaoping; Chang, Ronald K; Embrey, Mark W; Sanders, John M; Tiscia, Heather E; Drolet, Robert E; Kern, Jonathan T; Sur, Sylvie M; Renger, John J; Bilodeau, Mark T; Kennedy, Matthew E; Parker, Eric M; Stamford, Andrew W; Nargund, Ravi; McCauley, John A; Miller, Michael W.
Afiliação
  • Scott JD; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • DeMong DE; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Greshock TJ; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Basu K; Merck & Co., Inc. , 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.
  • Dai X; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Harris J; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Hruza A; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Li SW; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Lin SI; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Liu H; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Macala MK; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Hu Z; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Mei H; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Zhang H; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Walsh P; Merck & Co., Inc. , 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.
  • Poirier M; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Shi ZC; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Xiao L; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Agnihotri G; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Baptista MA; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Columbus J; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Fell MJ; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Hyde LA; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Kuvelkar R; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Lin Y; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Mirescu C; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Morrow JA; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Yin Z; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Zhang X; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Zhou X; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Chang RK; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Embrey MW; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Sanders JM; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Tiscia HE; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Drolet RE; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Kern JT; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Sur SM; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Renger JJ; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Bilodeau MT; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Kennedy ME; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Parker EM; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Stamford AW; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Nargund R; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • McCauley JA; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Miller MW; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
J Med Chem ; 60(7): 2983-2992, 2017 04 13.
Article em En | MEDLINE | ID: mdl-28245354
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Indazóis Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Indazóis Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Ano de publicação: 2017 Tipo de documento: Article