Improving enzymatic activities and thermostability of a tri-functional enzyme with SOD, catalase and cell-permeable activities.

Luangwattananun, Piriya; Eiamphungporn, Warawan; Songtawee, Napat; Bülow, Leif; Isarankura Na Ayudhya, Chartchalerm; Prachayasittikul, Virapong; Yainoy, Sakda

Luangwattananun, Piriya; Eiamphungporn, Warawan; Songtawee, Napat; Bülow, Leif; Isarankura Na Ayudhya, Chartchalerm; Prachayasittikul, Virapong; Yainoy, Sakda.

Afiliação

Luangwattananun P; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Eiamphungporn W; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Songtawee N; Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Bülow L; Pure and Applied Biochemistry, Department of Chemistry, Lund University, Lund SE-221 00, Sweden.
Isarankura Na Ayudhya C; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Prachayasittikul V; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Yainoy S; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand. Electronic address: sakda.yai@mahidol.ac.th.

J Biotechnol ; 247: 50-59, 2017 Apr 10.

Article em En | MEDLINE | ID: mdl-28274879

Assuntos

Antioxidantes/farmacologia; Catalase/genética; Engenharia de Proteínas/métodos; Proteínas Recombinantes/farmacologia; Superóxido Dismutase/genética; Animais; Antioxidantes/metabolismo; Catalase/metabolismo; Linhagem Celular; Permeabilidade da Membrana Celular; Movimento Celular/efeitos dos fármacos; Meia-Vida; Camundongos; Peso Molecular; Estresse Oxidativo/efeitos dos fármacos; Paraquat/efeitos adversos; Proteínas Recombinantes/metabolismo

Palavras-chave

Catalase; CuZnSOD; HIV-1 TAT; Protein engineering

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Proteínas Recombinantes / Engenharia de Proteínas / Catalase / Antioxidantes Limite: Animals Idioma: En Revista: J Biotechnol Ano de publicação: 2017 Tipo de documento: Article

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