AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5'-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

Kim, Ju-Hyun; Kwon, Soon-Sang; Kong, Tae Yeon; Cheong, Jae Chul; Kim, Hee Seung; In, Moon Kyo; Lee, Hye Suk

Kim, Ju-Hyun; Kwon, Soon-Sang; Kong, Tae Yeon; Cheong, Jae Chul; Kim, Hee Seung; In, Moon Kyo; Lee, Hye Suk.

Afiliação

Kim JH; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon 14662, Korea. jhyunkim@catholic.ac.kr.
Kwon SS; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon 14662, Korea. zuzutnseo@naver.com.
Kong TY; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon 14662, Korea. kongtaeyun@naver.com.
Cheong JC; Forensic Chemistry Laboratory, Forensic Science Division, Supreme Prosecutor's Office, 157 Banpo-daero, Seocho-gu, Seoul 06590, Korea. Saturn-jjc@spo.go.kr.
Kim HS; Forensic Chemistry Laboratory, Forensic Science Division, Supreme Prosecutor's Office, 157 Banpo-daero, Seocho-gu, Seoul 06590, Korea. hskjay@spo.go.kr.
In MK; Forensic Chemistry Laboratory, Forensic Science Division, Supreme Prosecutor's Office, 157 Banpo-daero, Seocho-gu, Seoul 06590, Korea. inmk@spo.go.kr.
Lee HS; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon 14662, Korea. sianalee@catholic.ac.kr.

Molecules ; 22(3)2017 Mar 10.

Article em En | MEDLINE | ID: mdl-28287454

Assuntos

Inibidores das Enzimas do Citocromo P-450/farmacologia; Sistema Enzimático do Citocromo P-450/metabolismo; Glucuronosiltransferase/antagonistas & inibidores; Indóis/farmacologia; Microssomos Hepáticos/enzimologia; Naftalenos/farmacologia; Cromatografia Líquida; Relação Dose-Resposta a Droga; Ativação Enzimática/efeitos dos fármacos; Humanos; Indóis/química; Concentração Inibidora 50; Isoenzimas; Estrutura Molecular; Naftalenos/química; Espectrometria de Massas em Tandem

Palavras-chave

AM-2201; UDP-glucuronosyltransferase inhibition; cytochrome P450 inhibition; drug-drug interaction; human liver microsomes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Glucuronosiltransferase / Sistema Enzimático do Citocromo P-450 / Inibidores das Enzimas do Citocromo P-450 / Indóis / Naftalenos Limite: Humans Idioma: En Revista: Molecules Ano de publicação: 2017 Tipo de documento: Article

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