Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study.
Clin Cardiol
; 40(6): 370-376, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28323322
ABSTRACT
BACKGROUND:
Repeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia-hyperoxia exposure in coronary artery disease (CAD) patients (New York Heart Association II-III).HYPOTHESIS:
IHHT improves exercise tolerance, cardiometabolic profile, and quality of life in CAD patients.METHODS:
The study design was a nonrandomized, controlled, before-and-after trial. Forty-six CAD patients volunteered to take part in the study a group of 27 patients undertook the intermittent hypoxia (O2 at 10%)-hyperoxia (O2 at 30%) training (IHHT), whereas a control group (CTRL) of 19 patients, who already completed an 8-week standard cardiac rehabilitation program, was allocated to sham-IHHT treatment (breathing room air, O2 at 21%). Exercise performance, blood and metabolic profiles, and quality of life (Seattle Angina Questionnaire [SAQ]) were measured before and after in the IHHT group (IHHG) and sham-IHHT in the CTRL group.RESULTS:
The IHHG showed improved exercise capacity, reduced systolic and diastolic blood pressures, enhanced left ventricle ejection fraction, and reduced glycemia, but only at 1-month follow-up. Angina as a reason to stop exercising was significantly reduced after treatment and at 1-month follow-up. The IHHT SAQ profile was improved in the IHHG and not significantly different to the CTRL group after standard rehabilitation. The IHHG was also compared to the CTRL group at 1-month follow-up, and no differences were found.CONCLUSIONS:
In CAD patients, an IHHT program is associated with improved exercise tolerance, healthier risks factors profile, and a better quality of life. Our study also suggests that IHHT is as effective as an 8-week standard rehabilitation program.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
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Doença da Artéria Coronariana
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Adaptação Fisiológica
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Tolerância ao Exercício
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Hiperóxia
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Terapia por Exercício
/
Hipóxia
Tipo de estudo:
Clinical_trials
Aspecto:
Patient_preference
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Cardiol
Ano de publicação:
2017
Tipo de documento:
Article