Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic.
J Clin Endocrinol Metab
; 102(4): 1350-1357, 2017 04 01.
Article
em En
| MEDLINE
| ID: mdl-28323984
ABSTRACT
Context Women with a history of infertility are at increased risk of impaired glucose tolerance during pregnancy. Studies suggest higher urinary bisphenol A (BPA) concentrations are associated with diabetes in nonpregnant populations, but the association between BPA and glucose levels among pregnant women is unclear. Objective:
To assess trimester-specific urinary BPA concentrations in relation to blood glucose levels among subfertile women.Design:
Environment and Reproductive Health Study, an ongoing prospective cohort study.Setting:
A fertility center in a teaching hospital. Patients A total of 245 women contributed at least one urine sample during first and/or second trimesters, delivered a singleton or twin pregnancy, and had available blood glucose data (2005 to 2015). Main OutcomeMeasure:
Blood glucose levels after a nonfasting 50-g glucose challenge test at 24 to 28 weeks of gestation.Results:
The specific gravity-adjusted geometric mean urinary BPA concentrations during first and second trimesters were 1.39 and 1.27 µg/L, respectively. Second-trimester BPA concentrations were positively associated with blood glucose (P, trend = 0.01). Specifically, the adjusted mean glucose levels (95% confidence interval) for women in the highest quartile of second-trimester BPA concentrations was 119 (112, 126) mg/dL compared with 106 (100, 112) mg/dL for women in the lowest quartile. No associations were observed between first-trimester BPA concentrations and glucose levels.Conclusions:
BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. As the findings represent the first report suggesting a potential etiologically relevant window for BPA and glucose in humans, further studies are needed.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Trimestres da Gravidez
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Compostos Benzidrílicos
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Glicemia
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Infertilidade
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Middle aged
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Pregnancy
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2017
Tipo de documento:
Article