Chiral exploration of 6,12-diphenyldibenzo[b,f][1,5]diazocine with stable conformation.
Chirality
; 29(3-4): 134-139, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28328107
ABSTRACT
A first optical resolution of 6,12-diphenyldibenzo[b,f][1,5]diazocine with stable boat conformation was achieved by chiral supercritical fluid chromatography (SFC). The absolute configurations of enantiomers were first assigned and determined by X-ray crystal structure based on CIP-rules. The high optical rotation and circular dichroism spectrum were well explained by electronic helix theory. Owing to the high stabilization of boat conformation, the chiral configuration could be maintained at very high temperature, more than 200 °C, which was proved by Density Functional Theory calculations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chirality
Ano de publicação:
2017
Tipo de documento:
Article