Apheresis in food allergies.
Curr Opin Allergy Clin Immunol
; 17(3): 227-231, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28350555
ABSTRACT
PURPOSE OF REVIEW The prevalence of IgE-mediated food allergy and anaphylaxis has risen rapidly in developed countries, and countries with rapid industrialization may follow. Therapies include elimination diets, Oral ImmunoTherapy, and the administration of biologics, but high serum IgE levels may preclude their use. Consequently, decreasing IgE becomes a rational approach and could be obtained by immunoapheresis. The aim of this review is to evaluate the rationale and advantages of immunoapheresis. RECENT FINDINGS:
The majority of the available adsorbers remove aspecifically all classes of immunoglobulins. Recently, IgE-specific adsorbers have been approved. Data on immunoapheresis for the treatment of allergic diseases with pathologically elevated IgE levels are emerging. In atopic dermatitis, this therapy alone seems to be beneficial. IgE-selective apheresis appears to be sufficient to reduce the risk of anaphylaxis in multiple food allergy (MFA) and, when IgE titers are high, to open the way to treatment with Omalizumab.SUMMARY:
Prospective studies, with well designed protocols, are needed to assess the efficacy, tolerability, and cost-effectiveness of immunoapheresis in the field of food allergy.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Remoção de Componentes Sanguíneos
/
Imunoglobulina E
/
Dermatite Atópica
/
Omalizumab
/
Hipersensibilidade Alimentar
/
Anafilaxia
/
Imunoterapia
Tipo de estudo:
Etiology_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Allergy Clin Immunol
Ano de publicação:
2017
Tipo de documento:
Article