Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour.
Artif Cells Nanomed Biotechnol
; 46(2): 255-262, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-28368657
ABSTRACT
To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). The cumulative permeation of IVM across excised rat skin from SLNs was significantly increased compared to the ivermection suspension. These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Ivermectina
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Portadores de Fármacos
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Nanopartículas
/
Lipídeos
Limite:
Animals
Idioma:
En
Revista:
Artif Cells Nanomed Biotechnol
Ano de publicação:
2018
Tipo de documento:
Article