Rheumatological complications of beta-thalassaemia: an overview.
Rheumatology (Oxford)
; 57(1): 19-27, 2018 01 01.
Article
em En
| MEDLINE
| ID: mdl-28371817
ABSTRACT
Beta-thalassaemia, an autosomal recessive haemoglobinopathy, ranks among the most frequent monogenetic diseases globally. The severe form of the disease, beta-thalassaemia major, is accompanied by progressive involvement of multiple organ systems as a result of the disease pathophysiology as well as iron overload from blood transfusions on a regular basis. Some of the manifestations might also be caused by medications used to manage iron overload. The purpose of this review is to highlight the rheumatological complications of beta-thalassaemia, which include musculoskeletal manifestations, such as arthritis and arthropathies, joint effusions, osteoporosis, bone fractures and myalgias, in addition to CTDs, such as pseudoxanthoma elasticum. Rheumatologists are strongly encouraged to take part in a multidisciplinary approach to the management of this debilitating disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue
/
Talassemia beta
/
Sobrecarga de Ferro
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Rheumatology (Oxford)
Ano de publicação:
2018
Tipo de documento:
Article