Evaluation of arterial stiffness by finger-toe pulse wave velocity: optimization of signal processing and clinical validation.
J Hypertens
; 35(8): 1618-1625, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-28379892
ABSTRACT
BACKGROUND:
Carotid-femoral pulse wave velocity (PWV) (cf-PWV) is the gold standard for measuring aortic stiffness. Finger-toe PWV (ft-PWV) is a simpler noninvasive method for measuring arterial stiffness. Although the validity of the method has been previously assessed, its accuracy can be improved. ft-PWV is determined on the basis of a patented height chart for the distance and the pulse transit time (PTT) between the finger and the toe pulpar arteries signals (ft-PTT).METHOD:
The objective of the first study, performed in 66 patients, was to compare different algorithms (intersecting tangents, maximum of the second derivative, 10% threshold and cross-correlation) for determining the foot of the arterial pulse wave, thus the ft-PTT. The objective of the second study, performed in 101 patients, was to investigate different signal processing chains to improve the concordance of ft-PWV with the gold-standard cf-PWV. Finger-toe PWV (ft-PWV) was calculated using the four algorithms.RESULTS:
The best correlations relating ft-PWV and cf-PWV, and relating ft-PTT and carotid-femoral PTT were obtained with the maximum of the second derivative algorithm [PWV râ=â0.56, Pâ<â0.0001, root mean square error (RMSE)â=â0.9âm/s; PTT râ=â0.61, Pâ<â0.001, RMSEâ=â12âms]. The three other algorithms showed lower correlations. The correlation between ft-PTT and carotid-femoral PTT further improved (râ=â0.81, Pâ<â0.0001, RMSEâ=â5.4âms) when the maximum of the second derivative algorithm was combined with an optimized signal processing chain.CONCLUSION:
Selecting the maximum of the second derivative algorithm for detecting the foot of the pressure waveform, and combining it with an optimized signal processing chain, improved the accuracy of ft-PWV measurement in the current population sample. Thus, it makes ft-PWV very promising for the simple noninvasive determination of aortic stiffness in clinical practice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Análise de Onda de Pulso
Tipo de estudo:
Evaluation_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Hypertens
Ano de publicação:
2017
Tipo de documento:
Article