High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival.

Helland, Å; Brustugun, O T; Nakken, S; Halvorsen, A R; Dønnem, T; Bremnes, R; Busund, L T; Sun, J; Lorenz, S; Solberg, S K; Jørgensen, L H; Vodak, D; Myklebost, O; Hovig, E; Meza-Zepeda, L A

Helland, Å; Brustugun, O T; Nakken, S; Halvorsen, A R; Dønnem, T; Bremnes, R; Busund, L T; Sun, J; Lorenz, S; Solberg, S K; Jørgensen, L H; Vodak, D; Myklebost, O; Hovig, E; Meza-Zepeda, L A.

Afiliação

Helland Å; Department of Cancer Genetics, Oslo University Hospital - Radium Hospital, Oslo, Norway.
Brustugun OT; Department of Oncology, Oslo University Hospital - Radium Hospital, Oslo, Norway.
Nakken S; Institute of Clinical Medicine, University of Oslo, Norway.
Halvorsen AR; Department of Cancer Genetics, Oslo University Hospital - Radium Hospital, Oslo, Norway.
Dønnem T; Department of Oncology, Oslo University Hospital - Radium Hospital, Oslo, Norway.
Bremnes R; Norwegian Cancer Genomics Consortium, Institute for Cancer Research, Oslo University Hospital -Radium Hospital, Oslo, Norway.
Busund LT; Department of Tumor Biology, Oslo University Hospital, Radium Hospital, Oslo, Norway.
Sun J; Department of Cancer Genetics, Oslo University Hospital - Radium Hospital, Oslo, Norway.
Lorenz S; Institute of Clinical Medicine, UiT - The Arctic University of Tromsø, Norway.
Solberg SK; Department of Oncology, University Hospital of Northern Norway, Tromsø, Norway.
Jørgensen LH; Institute of Clinical Medicine, UiT - The Arctic University of Tromsø, Norway.
Vodak D; Department of Oncology, University Hospital of Northern Norway, Tromsø, Norway.
Myklebost O; Institute of Medical Biology, The Arctic University of Norway, Tromsø, Norway.
Hovig E; Department of Pathology, University Hospital of Northern Norway, Tromsø, Norway.
Meza-Zepeda LA; Norwegian Cancer Genomics Consortium, Institute for Cancer Research, Oslo University Hospital -Radium Hospital, Oslo, Norway.

Int J Cancer ; 141(1): 184-190, 2017 07 01.

Article em En | MEDLINE | ID: mdl-28387924

Assuntos

Carcinoma Pulmonar de Células não Pequenas/genética; Imunidade Celular/genética; Proteínas de Neoplasias/genética; Fosfotransferases/genética; Adulto; Idoso; Carcinoma Pulmonar de Células não Pequenas/patologia; Intervalo Livre de Doença; Feminino; Genoma Humano; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Pessoa de Meia-Idade; Mutação; Recidiva Local de Neoplasia/genética; Recidiva Local de Neoplasia/patologia; Fosfotransferases/antagonistas & inibidores; Prognóstico; Inibidores de Proteínas Quinases/uso terapêutico

Palavras-chave

kinome; lung cancer; mutations; prognosis; sequencing

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Fosfotransferases / Carcinoma Pulmonar de Células não Pequenas / Imunidade Celular / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Ano de publicação: 2017 Tipo de documento: Article

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