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Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.
Galambos, János; Bielik, Attila; Wágner, Gábor; Domány, György; Kóti, János; Béni, Zoltán; Szigetvári, Áron; Sánta, Zsuzsanna; Orgován, Zoltán; Bobok, Amrita; Kiss, Béla; Mikó-Bakk, Mónika L; Vastag, Mónika; Sághy, Katalin; Krasavin, Mikhail; Gál, Krisztina; Greiner, István; Szombathelyi, Zsolt; Keseru, György M.
Afiliação
  • Galambos J; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Bielik A; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Wágner G; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
  • Domány G; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary. Electronic address: gy.domany@richter.hu.
  • Kóti J; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Béni Z; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Szigetvári Á; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Sánta Z; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Orgován Z; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, Budapest, 1117 Hungary.
  • Bobok A; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Kiss B; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Mikó-Bakk ML; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Vastag M; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Sághy K; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Krasavin M; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospekt, Peterhof 198504 Russia.
  • Gál K; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Greiner I; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Szombathelyi Z; Gedeon Richter Plc, 19-21 Gyömroi út, Budapest, 1103 Hungary.
  • Keseru GM; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, Budapest, 1117 Hungary. Electronic address: gy.keseru@ttk.mta.hu.
Eur J Med Chem ; 133: 240-254, 2017 Jun 16.
Article em En | MEDLINE | ID: mdl-28390229
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Receptor de Glutamato Metabotrópico 5 Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Receptor de Glutamato Metabotrópico 5 Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article