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Telomeres and the natural lifespan limit in humans.
Steenstrup, Troels; Kark, Jeremy D; Verhulst, Simon; Thinggaard, Mikael; Hjelmborg, Jacob V B; Dalgård, Christine; Kyvik, Kirsten Ohm; Christiansen, Lene; Mangino, Massimo; Spector, Timothy D; Petersen, Inge; Kimura, Masayuki; Benetos, Athanase; Labat, Carlos; Sinnreich, Ronit; Hwang, Shih-Jen; Levy, Daniel; Hunt, Steven C; Fitzpatrick, Annette L; Chen, Wei; Berenson, Gerald S; Barbieri, Michelangela; Paolisso, Giuseppe; Gadalla, Shahinaz M; Savage, Sharon A; Christensen, Kaare; Yashin, Anatoliy I; Arbeev, Konstantin G; Aviv, Abraham.
Afiliação
  • Steenstrup T; Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense 5000, Denmark.
  • Kark JD; Epidemiology Unit, Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem 91120, Israel.
  • Verhulst S; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Thinggaard M; Department of Clinical Genetics, Odense University Hospital, Odense 5220, Denmark.
  • Hjelmborg JVB; Danish Aging Research Center, University of Southern Denmark, Odense 5000, Denmark.
  • Dalgård C; Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense 5000, Denmark.
  • Kyvik KO; The Danish Twin Registry, University of Southern Denmark, Odense 5220, Denmark.
  • Christiansen L; Department of Public Health, Environmental Medicine, University of Southern Denmark, 5000 Odense C, Denmark.
  • Mangino M; Department of Clinical Research, University of Southern Denmark and Odense Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
  • Spector TD; Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense 5000, Denmark.
  • Petersen I; Danish Aging Research Center, University of Southern Denmark, Odense 5000, Denmark.
  • Kimura M; The Danish Twin Registry, University of Southern Denmark, Odense 5220, Denmark.
  • Benetos A; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Labat C; NIHI Biomedical Research Center at Guy's and St Thomas Foundation Trust, London SE1 9RT, UK.
  • Sinnreich R; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Hwang SJ; Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense 5000, Denmark.
  • Levy D; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
  • Hunt SC; Department of Geriatrics, University Hospital of Nancy, F54500, France.
  • Fitzpatrick AL; INSERM, U1116, Vandoeuvre-les-Nancy, F54500, France.
  • Chen W; Université de Lorraine, Nancy, F54000, France.
  • Berenson GS; INSERM, U1116, Vandoeuvre-les-Nancy, F54500, France.
  • Barbieri M; Université de Lorraine, Nancy, F54000, France.
  • Paolisso G; Epidemiology Unit, Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem 91120, Israel.
  • Gadalla SM; Population Sciences Branch of the National Heart, Lung and Blood Institute, Bethesda, MD and the Framingham Heart Study, Framingham, MA 01702, USA.
  • Savage SA; Population Sciences Branch of the National Heart, Lung and Blood Institute, Bethesda, MD and the Framingham Heart Study, Framingham, MA 01702, USA.
  • Christensen K; Cardiovascular Genetics Division, Department of Medicine, Cornell University, Ithaca, NY 14850 USA.
  • Yashin AI; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
  • Arbeev KG; Center for Cardiovascular Health, Tulane University, New Orleans, LA 07118, USA.
  • Aviv A; Center for Cardiovascular Health, Tulane University, New Orleans, LA 07118, USA.
Aging (Albany NY) ; 9(4): 1130-1142, 2017 04.
Article em En | MEDLINE | ID: mdl-28394764
An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telômero / Encurtamento do Telômero / Longevidade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Aging (Albany NY) Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telômero / Encurtamento do Telômero / Longevidade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Aging (Albany NY) Ano de publicação: 2017 Tipo de documento: Article