Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily.

Xia, Bo; Liu, Yinling; Guevara, Jose; Li, Jing; Jilich, Celeste; Yang, Ye; Wang, Liangjiang; Dominy, Brian N; Cao, Weiguo

Xia, Bo; Liu, Yinling; Guevara, Jose; Li, Jing; Jilich, Celeste; Yang, Ye; Wang, Liangjiang; Dominy, Brian N; Cao, Weiguo.

Afiliação

Xia B; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Liu Y; Department of Chemistry, Clemson University, 367 Hunter Laboratories, Clemson, SC 29634, USA.
Guevara J; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Li J; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Jilich C; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Yang Y; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Wang L; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.
Dominy BN; Department of Chemistry, Clemson University, 367 Hunter Laboratories, Clemson, SC 29634, USA.
Cao W; Department of Genetics and Biochemistry, Clemson University, Rooms 049 and 051 Life Sciences Facility, 190 Collings Street, Clemson, SC 29634, USA.

Sci Rep ; 7: 45978, 2017 04 11.

Article em En | MEDLINE | ID: mdl-28397787

Assuntos

Biocatálise; Evolução Biológica; Família Multigênica; Mutação/genética; Thermus thermophilus/enzimologia; Uracila-DNA Glicosidase/genética; Sequência de Aminoácidos; Substituição de Aminoácidos; Sítios de Ligação; Cinética; Modelos Moleculares; Proteínas Mutantes/química; Proteínas Mutantes/metabolismo; Alinhamento de Sequência; Especificidade por Substrato; Uracila/metabolismo; Uracila-DNA Glicosidase/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Família Multigênica / Thermus thermophilus / Uracila-DNA Glicosidase / Evolução Biológica / Biocatálise / Mutação Idioma: En Revista: Sci Rep Ano de publicação: 2017 Tipo de documento: Article

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