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Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.
Vöpel, Tobias; Bravo-Rodriguez, Kenny; Mittal, Sumit; Vachharajani, Shivang; Gnutt, David; Sharma, Abhishek; Steinhof, Anne; Fatoba, Oluwaseun; Ellrichmann, Gisa; Nshanian, Michael; Heid, Christian; Loo, Joseph A; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Wanker, Erich E; Ebbinghaus, Simon; Sanchez-Garcia, Elsa.
Afiliação
  • Vöpel T; Department of Physical Chemistry II, Ruhr-University Bochum , 44780 Bochum, Germany.
  • Bravo-Rodriguez K; Max-Planck-Institut für Kohlenforschung , 45470 Mülheim an der Ruhr, Germany.
  • Mittal S; Max-Planck-Institut für Kohlenforschung , 45470 Mülheim an der Ruhr, Germany.
  • Vachharajani S; Department of Physical Chemistry II, Ruhr-University Bochum , 44780 Bochum, Germany.
  • Gnutt D; Department of Physical Chemistry II, Ruhr-University Bochum , 44780 Bochum, Germany.
  • Sharma A; Department of Physical Chemistry II, Ruhr-University Bochum , 44780 Bochum, Germany.
  • Steinhof A; Max Delbrück Center for Molecular Medicine , 13125 Berlin, Germany.
  • Fatoba O; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum , 44780 Bochum, Germany.
  • Ellrichmann G; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum , 44780 Bochum, Germany.
  • Nshanian M; Department of Chemistry and Biochemistry, University of California at Los Angeles , Los Angeles, California 90095, United States.
  • Heid C; Institute of Organic Chemistry, University of Duisburg-Essen , 45141 Essen, Germany.
  • Loo JA; Department of Chemistry and Biochemistry, University of California at Los Angeles , Los Angeles, California 90095, United States.
  • Klärner FG; Department of Biological Chemistry and UCLA/DOE Institute of Genomics and Proteomics, University of California at Los Angeles , Los Angeles, California 90095, United States.
  • Schrader T; Institute of Organic Chemistry, University of Duisburg-Essen , 45141 Essen, Germany.
  • Bitan G; Institute of Organic Chemistry, University of Duisburg-Essen , 45141 Essen, Germany.
  • Wanker EE; Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles , Los Angeles, California 90095-7334, United States.
  • Ebbinghaus S; Max Delbrück Center for Molecular Medicine , 13125 Berlin, Germany.
  • Sanchez-Garcia E; Department of Physical Chemistry II, Ruhr-University Bochum , 44780 Bochum, Germany.
J Am Chem Soc ; 139(16): 5640-5643, 2017 04 26.
Article em En | MEDLINE | ID: mdl-28406616
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organofosfatos / Hidrocarbonetos Aromáticos com Pontes / Proteína Huntingtina Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organofosfatos / Hidrocarbonetos Aromáticos com Pontes / Proteína Huntingtina Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2017 Tipo de documento: Article