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Age-dependent variation of fecal calprotectin in cystic fibrosis and healthy children.
Garg, Millie; Leach, Steven T; Coffey, Michael J; Katz, Tamarah; Strachan, Roxanne; Pang, Tamara; Needham, Bronwen; Lui, Kei; Ali, Fathalla; Day, Andrew S; Appleton, Laura; Moeeni, Vesal; Jaffe, Adam; Ooi, Chee Y.
Afiliação
  • Garg M; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
  • Leach ST; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
  • Coffey MJ; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
  • Katz T; Department of Nutrition and Dietetics, Sydney Children's Hospital, High Street, Randwick 2031, New South Wales, Australia.
  • Strachan R; Department of Respiratory Medicine, Sydney Children's Hospital, High Street, Randwick 2031, New South Wales, Australia.
  • Pang T; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
  • Needham B; Sydney Medical Program, The University of Sydney, Camperdown 2050, New South Wales, Australia.
  • Lui K; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia; Department of Newborn Care, The Royal Hospital for Women, Barker Street, Randwick 2031, New South Wales, Australia.
  • Ali F; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
  • Day AS; Department of Pediatrics, University of Otago, 2 Riccarton Ave, Christchurch 8011, Canterbury, New Zealand.
  • Appleton L; Department of Pediatrics, University of Otago, 2 Riccarton Ave, Christchurch 8011, Canterbury, New Zealand.
  • Moeeni V; Department of Pediatrics, University of Otago, 2 Riccarton Ave, Christchurch 8011, Canterbury, New Zealand.
  • Jaffe A; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia; Department of Respiratory Medicine, Sydney Children's Hospital, High Street, Randwick 2031, New South Wales, Australia.
  • Ooi CY; School of Women's and Children's Health, Medicine, The University of New South Wales, Sydney, New South Wales, Australia; Department of Gastroenterology, Sydney Children's Hospital, High Street, Randwick 2031, New South Wales, Australia. Electronic address: keith.ooi@unsw.edu.au.
J Cyst Fibros ; 16(5): 631-636, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28416415
ABSTRACT

BACKGROUND:

Fecal calprotectin may be used as a non-invasive method to assess the effect of novel therapies on the gut in cystic fibrosis (CF).

METHOD:

Stools from CF patients and healthy controls (HC) (0-10years old) were prospectively collected for evaluation of temporal trends.

RESULTS:

130 CF samples (64 subjects) and 114 HC samples (101 subjects) were collected. Overall, fecal calprotectin levels were different in CF patients and HC from 0 to 10years (P=0.0002). Fecal calprotectin in CF was significantly lower than HC from 0 to 1years (P=0.03) and demonstrated an upward trajectory until 4years. From >4 to 10years calprotectin was consistently higher in CF patients compared with HC (P=0.007).

CONCLUSIONS:

Fecal calprotectin levels in children with CF and HC were age-dependent and had distinct trajectories. Careful interpretation of calprotectin is required if used in drug trials for CF, particularly in children less than 4years old.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Cística / Complexo Antígeno L1 Leucocitário / Fezes / Inflamação / Mucosa Intestinal / Intestinos Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Cyst Fibros Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Cística / Complexo Antígeno L1 Leucocitário / Fezes / Inflamação / Mucosa Intestinal / Intestinos Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Cyst Fibros Ano de publicação: 2017 Tipo de documento: Article