Age-dependent variation of fecal calprotectin in cystic fibrosis and healthy children.
J Cyst Fibros
; 16(5): 631-636, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28416415
ABSTRACT
BACKGROUND:
Fecal calprotectin may be used as a non-invasive method to assess the effect of novel therapies on the gut in cystic fibrosis (CF).METHOD:
Stools from CF patients and healthy controls (HC) (0-10years old) were prospectively collected for evaluation of temporal trends.RESULTS:
130 CF samples (64 subjects) and 114 HC samples (101 subjects) were collected. Overall, fecal calprotectin levels were different in CF patients and HC from 0 to 10years (P=0.0002). Fecal calprotectin in CF was significantly lower than HC from 0 to 1years (P=0.03) and demonstrated an upward trajectory until 4years. From >4 to 10years calprotectin was consistently higher in CF patients compared with HC (P=0.007).CONCLUSIONS:
Fecal calprotectin levels in children with CF and HC were age-dependent and had distinct trajectories. Careful interpretation of calprotectin is required if used in drug trials for CF, particularly in children less than 4years old.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose Cística
/
Complexo Antígeno L1 Leucocitário
/
Fezes
/
Inflamação
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Mucosa Intestinal
/
Intestinos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
J Cyst Fibros
Ano de publicação:
2017
Tipo de documento:
Article