Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions.
Oral Dis
; 23(7): 973-982, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28419681
ABSTRACT
OBJECTIVE:
Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS ANDMETHODS:
The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded. Fungal populations in the saliva were evaluated by PCR-based molecular techniques. Body mass index (BMI), smoking habits, and oral health conditions were examined.RESULTS:
Salivary fungal amounts exceeded 104 CFU/ml in 63 (15.4%) of 410 subjects. Candida albicans was most frequently detected (98.4%), followed by Candida glabrata (54.0%), and Candida dubliniensis (38.1%) in those subjects with fungi at 104 CFU/ml or over. Fungi at 104 CFU/ml or over in the presence of C. glabrata or C. dubliniensis was significantly associated with low BMI.CONCLUSIONS:
Candida albicans, C. glabrata, and C. dubliniensis dominated the oral mycobiome in Japanese community-dwelling elderly. Lower BMI might signify compromised health status and thus could result in susceptibility to specific candidiasis by C. glabrata and C. dubliniensis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
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Candida
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Nível de Saúde
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Micobioma
Aspecto:
Determinantes_sociais_saude
/
Patient_preference
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Oral Dis
Ano de publicação:
2017
Tipo de documento:
Article