Associations of Osteocalcin, Osteoprotegerin, and Calcitonin with Inflammation Biomarkers in Atherosclerotic Plaques of Coronary Arteries.
Bull Exp Biol Med
; 162(6): 726-729, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28429221
ABSTRACT
We studied associations of osteocalcin, osteoprotegerin, and calcitonin with markers of inflammation in atherosclerotic plaques in coronary arteries and assessed the influence of these biomolecules on calcification of atherosclerotic plaques. The initial stage of calcification of atherosclerotic plaques is characterized by activation of inflammatory processes, which is seen from increased levels of proinflammatory biomarkers (IL-6, IL 8, TNF-α, and IL-1ß). Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin. The exception is osteocalcin, its concentration significantly increased during calcification. The results suggest that severe vascular calcification can be regarded as non-specific marker of atherosclerosis. Instability of atherosclerotic plaques is associated with higher level of calcification.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calcitonina
/
Osteocalcina
/
Aterosclerose
/
Osteoprotegerina
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Placa Aterosclerótica
/
Calcificação Vascular
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2017
Tipo de documento:
Article