Regenerative Medicine and Stem Cells in Dermatology.
Dermatol Surg
; 43(5): 625-634, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28441301
ABSTRACT
BACKGROUND:
Clinically relevant regenerative medicine is still in its early stages of development. Difficulties in regenerating large-scale and complex structures, the lack of safety data, and the paucity of clinical trials have slowed the process of technological advance.OBJECTIVE:
To familiarize the clinician with techniques available in the laboratory and experimental approaches being tested clinically. In addition, a layout is discussed for how dermatologists can lead the way in bringing regenerative medicine to clinical reality.METHODS:
This article reviews the relevant literature on regenerative medicine for dermatological applications and discusses findings and techniques in a clinically relevant context.RESULTS:
Multiple cell-free and cell-based approaches for regenerating dermatologic tissues have been reported in the basic science and clinical literature. These are reviewed in the order of complexity.CONCLUSION:
Incremental steps are needed to apply the principles of regenerative medicine to simple medical problems first. Such a stepwise approach would commence, for example, with creation of single-function tissues that could fill soft-tissue defects and proceed to the development of fully functional skin grafts. Likewise, cell-free approaches can build the foundation for the more technically demanding cell-based strategies that are likely necessary for achieving the ultimate goal of regenerative dermatology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Medicina Regenerativa
/
Dermatologia
Limite:
Humans
Idioma:
En
Revista:
Dermatol Surg
Ano de publicação:
2017
Tipo de documento:
Article