Development of a Biorelevant, Material-Sparing Membrane Flux Test for Rapid Screening of Bioavailability-Enhancing Drug Product Formulations.

Stewart, Aaron M; Grass, Michael E; Mudie, Deanna M; Morgen, Michael M; Friesen, Dwayne T; Vodak, David T

Stewart, Aaron M; Grass, Michael E; Mudie, Deanna M; Morgen, Michael M; Friesen, Dwayne T; Vodak, David T.

Afiliação

Stewart AM; Global Research and Development, Pharmaceutical Science, Capsugel , Bend, Oregon 97701, United States.
Grass ME; Global Research and Development, Pharmaceutical Science, Capsugel , Bend, Oregon 97701, United States.
Mudie DM; Global Research and Development, Pharmaceutical Science, Capsugel , Bend, Oregon 97701, United States.
Morgen MM; Global Research and Development, Pharmaceutical Science, Capsugel , Bend, Oregon 97701, United States.
Friesen DT; Global Research and Development, Pharmaceutical Science, Capsugel , Bend, Oregon 97701, United States.
Vodak DT; Global Research and Development, Pharmaceutical Science, Capsugel , Bend, Oregon 97701, United States.

Mol Pharm ; 14(6): 2032-2046, 2017 06 05.

Article em En | MEDLINE | ID: mdl-28441497

Assuntos

Composição de Medicamentos/métodos; Administração Oral; Disponibilidade Biológica; Coloides/química; Itraconazol/química; Cetoconazol/química; Micelas; Solubilidade

Palavras-chave

diffusion; dissolution rate; drug/polymer colloids; flux; itraconazole; ketoconazole; membrane; spray-dried dispersion; unstirred water layer

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Composição de Medicamentos Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Mol Pharm Ano de publicação: 2017 Tipo de documento: Article

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