Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-&#954;B Activation and Cell Survival.

Horn, Sebastian; Hughes, Michelle A; Schilling, Ramon; Sticht, Carsten; Tenev, Tencho; Ploesser, Michaela; Meier, Pascal; Sprick, Martin R; MacFarlane, Marion; Leverkus, Martin

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.

Horn, Sebastian; Hughes, Michelle A; Schilling, Ramon; Sticht, Carsten; Tenev, Tencho; Ploesser, Michaela; Meier, Pascal; Sprick, Martin R; MacFarlane, Marion; Leverkus, Martin.

Afiliação

Horn S; Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address: sebastian-horn@gmx.net.
Hughes MA; MRC Toxicology Unit, Hodgkin Building, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK.
Schilling R; Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Sticht C; Center for Medical Research, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Tenev T; The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.
Ploesser M; Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Meier P; The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.
Sprick MR; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address: m.sprick@dkfz-heidelberg.de.
MacFarlane M; MRC Toxicology Unit, Hodgkin Building, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK. Electronic address: mm21@leicester.ac.uk.
Leverkus M; Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; Department of Dermatology and Allergology, Medical Faculty of the RWTH Aachen, Pauwelsstraße 30, 52074 Aach

Cell Rep ; 19(4): 785-797, 2017 04 25.

Article em En | MEDLINE | ID: mdl-28445729

Assuntos

Apoptose/efeitos dos fármacos; Caspase 10/metabolismo; Caspase 8/metabolismo; Proteína Ligante Fas/farmacologia; NF-kappa B/metabolismo; Proteína Reguladora de Apoptosis Semelhante a CASP8 e FADD/antagonistas & inibidores; Proteína Reguladora de Apoptosis Semelhante a CASP8 e FADD/genética; Proteína Reguladora de Apoptosis Semelhante a CASP8 e FADD/metabolismo; Caspase 10/química; Caspase 10/genética; Caspase 8/química; Caspase 8/genética; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/genética; Proteína de Domínio de Morte Associada a Fas/metabolismo; Células HeLa; Humanos; Imidazóis/farmacologia; Indóis/farmacologia; Interleucina-8/genética; Interleucina-8/metabolismo; Inibidor de NF-kappaB alfa/metabolismo; Oligopeptídeos/farmacologia; Interferência de RNA; RNA Mensageiro; RNA Interferente Pequeno/metabolismo; Transdução de Sinais; Receptor fas/metabolismo

Palavras-chave

CD95; DISC; NF-κB; cFLIP; caspase-10; caspase-8; cell death

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Apoptose / Caspase 8 / Caspase 10 / Proteína Ligante Fas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google