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Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Schneider, Rebekka K; Mullally, Ann; Dugourd, Aurelien; Peisker, Fabian; Hoogenboezem, Remco; Van Strien, Paulina M H; Bindels, Eric M; Heckl, Dirk; Büsche, Guntram; Fleck, David; Müller-Newen, Gerhard; Wongboonsin, Janewit; Ventura Ferreira, Monica; Puelles, Victor G; Saez-Rodriguez, Julio; Ebert, Benjamin L; Humphreys, Benjamin D; Kramann, Rafael.
Afiliação
  • Schneider RK; Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: r.k.schneider@erasmusmc.nl.
  • Mullally A; Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Dugourd A; Joint Research Centre for Computational Biomedicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Peisker F; Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany.
  • Hoogenboezem R; Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands.
  • Van Strien PMH; Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands.
  • Bindels EM; Department of Hematology, Erasmus MC Cancer Institute, 3015CN Rotterdam, the Netherlands.
  • Heckl D; Division of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
  • Büsche G; Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany.
  • Fleck D; Department of Chemosensation, Institute of Biology II, RWTH Aachen University, 52074 Aachen, Germany.
  • Müller-Newen G; Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52074 Aachen, Germany.
  • Wongboonsin J; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700 Bangkok, Thailand.
  • Ventura Ferreira M; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, 52074 Aachen, Germany.
  • Puelles VG; Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany.
  • Saez-Rodriguez J; Joint Research Centre for Computational Biomedicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Ebert BL; Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Humphreys BD; Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Kramann R; Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: rkramann@gmx.net.
Cell Stem Cell ; 20(6): 785-800.e8, 2017 06 01.
Article em En | MEDLINE | ID: mdl-28457748
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirimidinas / Diferenciação Celular / Proliferação de Células / Mielofibrose Primária / Miofibroblastos / Células-Tronco Mesenquimais / Proteína GLI1 em Dedos de Zinco Limite: Animals / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirimidinas / Diferenciação Celular / Proliferação de Células / Mielofibrose Primária / Miofibroblastos / Células-Tronco Mesenquimais / Proteína GLI1 em Dedos de Zinco Limite: Animals / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2017 Tipo de documento: Article