A Robust Framework for Microbial Archaeology.
Annu Rev Genomics Hum Genet
; 18: 321-356, 2017 08 31.
Article
em En
| MEDLINE
| ID: mdl-28460196
ABSTRACT
Microbial archaeology is flourishing in the era of high-throughput sequencing, revealing the agents behind devastating historical plagues, identifying the cryptic movements of pathogens in prehistory, and reconstructing the ancestral microbiota of humans. Here, we introduce the fundamental concepts and theoretical framework of the discipline, then discuss applied methodologies for pathogen identification and microbiome characterization from archaeological samples. We give special attention to the process of identifying, validating, and authenticating ancient microbes using high-throughput DNA sequencing data. Finally, we outline standards and precautions to guide future research in the field.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Archaea
/
Análise de Sequência de DNA
/
Metagenômica
/
Microbiota
/
DNA Antigo
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Genomics Hum Genet
Ano de publicação:
2017
Tipo de documento:
Article