Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKÎµ-IRF3 complex.

Huang, Li; Xiong, Tao; Yu, Huibin; Zhang, Quan; Zhang, Kunli; Li, Changyao; Hu, Liang; Zhang, Yuanfeng; Zhang, Lijie; Liu, Qinfang; Wang, Shengnan; He, Xijun; Bu, Zhigao; Cai, Xuehui; Cui, Shangjin; Li, Jiangnan; Weng, Changjiang

Huang, Li; Xiong, Tao; Yu, Huibin; Zhang, Quan; Zhang, Kunli; Li, Changyao; Hu, Liang; Zhang, Yuanfeng; Zhang, Lijie; Liu, Qinfang; Wang, Shengnan; He, Xijun; Bu, Zhigao; Cai, Xuehui; Cui, Shangjin; Li, Jiangnan; Weng, Changjiang.

Afiliação

Huang L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Xiong T; College of Life Sciences, Yangtze University, Jingzhou 434100, China.
Yu H; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Zhang Q; College of Life Sciences, Yangtze University, Jingzhou 434100, China.
Zhang K; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Li C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Hu L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Zhang Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Zhang L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Liu Q; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Wang S; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
He X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Bu Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Cai X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China.
Cui S; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China cuishangjin@126.com lijiangnan521@163.com wengchji@163.com.
Li J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China cuishangjin@126.com lijiangnan521@163.com wengchji@163.com.
Weng C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, Heilongjiang 150069, China cuishangjin@126.com lijiangnan521@163.com wengchji@163.com.

Biochem J ; 474(12): 2051-2065, 2017 06 09.

Article em En | MEDLINE | ID: mdl-28487378

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/antagonistas & inibidores; Cisteína Endopeptidases/metabolismo; Vírus da Encefalomiocardite/enzimologia; Quinase I-kappa B/antagonistas & inibidores; Fator Regulador 3 de Interferon/antagonistas & inibidores; Interferon Tipo I/antagonistas & inibidores; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Proteínas Virais/metabolismo; Proteases Virais 3C; Proteínas Adaptadoras de Transdução de Sinal/química; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Substituição de Aminoácidos; Animais; Linhagem Celular; Cisteína Endopeptidases/química; Cisteína Endopeptidases/genética; Cães; Deleção de Genes; Humanos; Quinase I-kappa B/química; Quinase I-kappa B/genética; Quinase I-kappa B/metabolismo; Fator Regulador 3 de Interferon/química; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Interferon Tipo I/biossíntese; Mesocricetus; Mutagênese Sítio-Dirigida; Mutação; Fragmentos de Peptídeos/antagonistas & inibidores; Fragmentos de Peptídeos/química; Fragmentos de Peptídeos/genética; Fragmentos de Peptídeos/metabolismo; Fosforilação; Multimerização Proteica; Processamento de Proteína Pós-Traducional; Proteínas Serina-Treonina Quinases/química; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Proteólise; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/metabolismo; Proteínas Virais/química; Proteínas Virais/genética

Palavras-chave

3C protease; IKKÎµ; TANK; TBK1; encephalomyocarditis virus; interferon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Cisteína Endopeptidases / Interferon Tipo I / Proteínas Serina-Treonina Quinases / Proteínas Adaptadoras de Transdução de Sinal / Vírus da Encefalomiocardite / Quinase I-kappa B / Fator Regulador 3 de Interferon Idioma: En Revista: Biochem J Ano de publicação: 2017 Tipo de documento: Article

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