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Uptake Kinetics and Subcellular Compartmentalization Explain Lethal but Not Sublethal Effects of Cadmium in Two Closely Related Amphipod Species.

Jakob, Lena; Bedulina, Daria S; Axenov-Gribanov, Denis V; Ginzburg, Michael; Shatilina, Zhanna M; Lubyaga, Yulia A; Madyarova, Ekaterina V; Gurkov, Anton N; Timofeyev, Maxim A; Pörtner, Hans-O; Sartoris, Franz J; Altenburger, Rolf; Luckenbach, Till.
Environ Sci Technol; 51(12): 7208-7218, 2017 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-28493692
Eulimnogammarus cyaneus and Eulimnogammarus verrucosus, closely related amphipod species endemic to Lake Baikal, differ with respect to body size (10- to 50-fold lower fresh weights of E. cyaneus) and cellular stress response (CSR) capacity, potentially causing species-related differences in uptake, internal sequestration, and toxic sensitivity to waterborne cadmium (Cd). We found that, compared to E. verrucosus, Cd uptake rates, related to a given exposure concentration, were higher, and lethal concentrations (50%; LC50) were 2.3-fold lower in E. cyaneus (4 weeks exposure; 6 °C). Upon exposures to species-specific subacutely toxic Cd concentrations (nominal LC1; E. cyaneus 18 nM (2.0 µg L-1); E. verrucosus 115 nM (12.9 µg L-1); 4 weeks exposure; 6 °C), Cd amounts in metal sensitive tissue fractions (MSF), in relation to fresh weight, were similar in both species (E. cyaneus 0.25 ± 0.06 µg g-1; E. verrucosus 0.26 ± 0.07 µg g-1), whereas relative Cd amounts in the biologically detoxified heat stable protein fraction were 35% higher in E. cyaneus. Despite different potencies in detoxifying Cd, body size appears to mainly explain species-related differences in Cd uptake and sensitivities. When exposed to Cd at LC1 over 4 weeks, only E. verrucosus continuously showed 15-36% reduced oxygen consumption rates indicating metabolic depression and pointing to particular sensitivity of E. verrucosus to persisting low-level toxicant pressure.
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