The Complex Diagnostic Challenge in Children With Non-Central Nervous System Cancer and Cerebellar Mutism.
J Child Neurol
; 32(9): 823-827, 2017 08.
Article
em En
| MEDLINE
| ID: mdl-28497710
ABSTRACT
Multiple etiologies should be considered in the differential diagnosis of immunocompromised patients with non-central nervous system cancer and viral infections who develop mutism. Acute cerebellitis, caused by infections or by neurotoxicity resulting from chemotherapy; paraneoplastic cerebellar degeneration; atypical posterior reversible encephalopathy syndrome; and acute disseminated encephalomyelitis may all cause mutism in such patients. This condition warrants prompt recognition and may require treatment with immunotherapy, as it may be an immune-mediated process. We present 2 patients with leukemia and viral illness who developed cerebellar mutism in the setting of acute cerebellitis and responded to immunotherapy, suggesting that the condition involved a parainfectious immune-mediated response.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
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Leucemia
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Doenças Cerebelares
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Mutismo
Tipo de estudo:
Diagnostic_studies
Limite:
Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
J Child Neurol
Ano de publicação:
2017
Tipo de documento:
Article