Effect of zinc deprivation on the lipid metabolism of budding yeast.
Curr Genet
; 63(6): 977-982, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28500379
ABSTRACT
Zinc is an essential micronutrient for all living cells. It serves as a structural and catalytic cofactor for numerous proteins, hence maintaining a proper level of cellular zinc is essential for normal functioning of the cell. Zinc homeostasis is sustained through various ways under severe zinc-deficient conditions. Zinc-dependent proteins play an important role in biological systems and limitation of zinc causes a drastic change in their expression. In budding yeast, a zinc-responsive transcription factor Zap1p controls the expression of genes required for uptake and mobilization of zinc under zinc-limiting conditions. It also regulates the polar lipid levels under zinc-limiting conditions to maintain membrane integrity. Deletion of ZAP1 causes an increase in triacylglyerol levels which is due to the increased biosynthesis of acetate that serves as a precursor for triacylglycerol biosynthesis. In this review, we expanded our recent work role of Zap1p in nonpolar lipid metabolism of budding yeast.
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MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Fatores de Transcrição
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Triglicerídeos
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Zinco
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Regulação Fúngica da Expressão Gênica
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Proteínas de Saccharomyces cerevisiae
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Metabolismo dos Lipídeos
Idioma:
En
Revista:
Curr Genet
Ano de publicação:
2017
Tipo de documento:
Article