Mangiferin protects against âintestinal ischemia/reperfusion-induced âliver injury: â¬â¬Involvement of PPAR-âγ, GSK-3ß and Wnt/ß-catenin pathwayâ¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬â¬.
Eur J Pharmacol
; 809: 80-86, 2017 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-28506911
ABSTRACT
AIM:
Mangiferin (MF), a xanthonoid from Mangifera indica, possesses anti-inflammatory, immunomodulatory, and potent antioxidant effects; however, its protective effect against mesenteric ischemia/reperfusion (I/R)-induced liver injury has not been fully clarified. The study was designed to assess the possible mechanism of action of MF against mesenteric I/R model. MAINMETHODS:
Male Wister rats were treated with MF (20mg/kg, i.p) or the vehicle for 3 days before I/R, which was induced by clamping the superior mesenteric artery for 30min followed by declamping for 60min. KEYFINDINGS:
The mechanistic studies revealed that MF protected the 2 organs studied, viz., liver and intestine partly via increasing the content of ß-catenin and PPAR-γ along with decreasing that of GSK-3ß and the phosphorylated NF-ÒB-p65. MF antioxidant effect was evidenced by increasing contents of total antioxidant capacity and GST, besides normalizing that of MDA. Regarding the anti-inflammatory effect, MF reduced IL-1ß and IL-6, effects that were mirrored on the tissue content of MPO. Moreover, MF possessed anti-apoptotic character evidenced by elevating Bcl-2 content and reducing that of caspase-3. In the serum, intestinal I/R increased the activity of ALT, AST, and creatine kinase.SIGNIFICANCE:
The intimated protective mechanisms of MF against mesenteric I/R are mediated, partially, by modulation of oxidative stress, inflammation, and apoptosis possibly via the involvement of Wnt/ß-catenin/NF-Òß/ PPAR-γ signaling pathways.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
Xantonas
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PPAR gama
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Via de Sinalização Wnt
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Glicogênio Sintase Quinase 3 beta
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Intestinos
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Fígado
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2017
Tipo de documento:
Article