Brown adipose tissue detected by PET/CT imaging is associated with less central obesity.
Nucl Med Commun
; 38(7): 629-635, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28509766
ABSTRACT
PURPOSE:
This retrospective review was performed to determine whether patients with brown adipose tissue (BAT) detected by fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging have less central obesity than BMI-matched control patients without detectable BAT. PATIENTS ANDMETHODS:
Thirty-seven adult oncology patients with F-FDG BAT uptake were retrospectively identified from PET/CT studies from 2011 to 2013. The control cohort consisted of 74 adult oncology patients without detectable F-FDG BAT uptake matched for BMI/sex/season. Tissue fat content was estimated by CT density (Hounsfield units) with a subsequent noise removal step. Total fat and abdominal fat were calculated. An automated separation algorithm was utilized to determine the visceral fat and subcutaneous fat at the L4/L5 level. In addition, liver density was obtained from CT images. CT imaging was interpreted blinded to clinical information.RESULTS:
There was no difference in total fat for the BAT cohort (34±15 l) compared with the controls (34±16 l) (P=0.96). The BAT cohort had lower abdominal fat to total fat ratio compared with the controls (0.28±0.05 vs. 0.31±0.08, respectively; P=0.01). The BAT cohort had a lower visceral fat/(visceral fat+subcutaneous fat) ratio compared with the controls (0.30±0.10 vs. 0.34±0.12, respectively; P=0.03). Patients with BAT had higher liver density, suggesting less liver fat, compared with the controls (51.3±7.5 vs. 47.1±7.0 HU, P=0.003).CONCLUSION:
The findings suggest that active BAT detected by F-FDG PET/CT is associated with less central obesity and liver fat. The presence of foci of BAT may be protective against features of the metabolic syndrome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo Marrom
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Obesidade Abdominal
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Nucl Med Commun
Ano de publicação:
2017
Tipo de documento:
Article