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Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration.
Zubiría, María Guillermina; Gambaro, Sabrina Eliana; Rey, María Amanda; Carasi, Paula; Serradell, María de Los Ángeles; Giovambattista, Andrés.
Afiliação
  • Zubiría MG; Neuroendocrinology Laboratory, Multidisciplinary Institute of Cellular Biology (IMBICE, CICPBA-CONICET-UNLP), 526 10 y 11, La Plata 1900, Argentina. gzubiria@imbice.gov.ar.
  • Gambaro SE; Biology Department, School of Exact Sciences, Universidad Nacional de La Plata, La Plata 1900, Argentina. gzubiria@imbice.gov.ar.
  • Rey MA; Neuroendocrinology Laboratory, Multidisciplinary Institute of Cellular Biology (IMBICE, CICPBA-CONICET-UNLP), 526 10 y 11, La Plata 1900, Argentina. sabrigambaro@gmail.com.
  • Carasi P; Neuroendocrinology Laboratory, Multidisciplinary Institute of Cellular Biology (IMBICE, CICPBA-CONICET-UNLP), 526 10 y 11, La Plata 1900, Argentina. mamandarey@gmail.com.
  • Serradell MLÁ; Cátedra de Microbiología, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), 47 y 115 s/n, La Plata 1900, Argentina. paulacarasi@gmail.com.
  • Giovambattista A; Cátedra de Microbiología, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), 47 y 115 s/n, La Plata 1900, Argentina. maserr@biol.unlp.edu.ar.
Nutrients ; 9(5)2017 May 17.
Article em En | MEDLINE | ID: mdl-28513533
Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% w/v) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1ß; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carboidratos da Dieta / Frutose / Lactobacillus Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carboidratos da Dieta / Frutose / Lactobacillus Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2017 Tipo de documento: Article