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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.
Hastings, Nicholas B; Wang, Xiaohai; Song, Lixin; Butts, Brent D; Grotz, Diane; Hargreaves, Richard; Fred Hess, J; Hong, Kwok-Lam Karen; Huang, Cathy Ruey-Ruey; Hyde, Lynn; Laverty, Maureen; Lee, Julie; Levitan, Diane; Lu, Sherry X; Maguire, Maureen; Mahadomrongkul, Veeravan; McEachern, Ernest J; Ouyang, Xuesong; Rosahl, Thomas W; Selnick, Harold; Stanton, Michaela; Terracina, Giuseppe; Vocadlo, David J; Wang, Ganfeng; Duffy, Joseph L; Parker, Eric M; Zhang, Lili.
Afiliação
  • Hastings NB; Department of Neuroscience, Kenilworth, NJ, USA.
  • Wang X; Department of In Vivo Pharmacology, West Point, PA, USA.
  • Song L; Department of Neuroscience, Kenilworth, NJ, USA.
  • Butts BD; Department of Molecular Biomarkers, Kenilworth, NJ, USA.
  • Grotz D; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Kenilworth, NJ, USA.
  • Hargreaves R; Department of Neuroscience, West Point, PA, USA.
  • Fred Hess J; Department of Neuroscience, Kenilworth, NJ, USA.
  • Hong KK; Department of Neuroscience, Kenilworth, NJ, USA.
  • Huang CR; Department of Neuroscience, Kenilworth, NJ, USA.
  • Hyde L; Department of Neuroscience, Kenilworth, NJ, USA.
  • Laverty M; Department of Molecular Biomarkers, Kenilworth, NJ, USA.
  • Lee J; Department of Neuroscience, Kenilworth, NJ, USA.
  • Levitan D; Department of Molecular Biomarkers, Kenilworth, NJ, USA.
  • Lu SX; Department of Neuroscience, Kenilworth, NJ, USA.
  • Maguire M; Department of Molecular Biomarkers, Kenilworth, NJ, USA.
  • Mahadomrongkul V; Department of Neuroscience, Kenilworth, NJ, USA.
  • McEachern EJ; Alectos Therapeutics Inc., Burnaby, BC, Canada.
  • Ouyang X; Department of Neuroscience, Kenilworth, NJ, USA.
  • Rosahl TW; Department of In Vivo Pharmacology, Kenilworth, NJ, USA.
  • Selnick H; Discovery Chemistry, Merck Research Laboratories, West Point, PA, USA.
  • Stanton M; Department of Neuroscience, Kenilworth, NJ, USA.
  • Terracina G; Department of Neuroscience, Kenilworth, NJ, USA.
  • Vocadlo DJ; Alectos Therapeutics Inc., Burnaby, BC, Canada.
  • Wang G; Department of Neuroscience, West Point, PA, USA.
  • Duffy JL; Discovery Chemistry Merck Research Laboratories, Kenilworth, NJ, USA. joseph_duffy@merck.com.
  • Parker EM; Department of Neuroscience, Kenilworth, NJ, USA. ericmcparker@comcast.net.
  • Zhang L; Department of Neuroscience, Kenilworth, NJ, USA. llzh@icloud.com.
Mol Neurodegener ; 12(1): 39, 2017 05 18.
Article em En | MEDLINE | ID: mdl-28521765
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Beta-N-Acetil-Hexosaminidases / Proteínas tau / Tauopatias Limite: Animals Idioma: En Revista: Mol Neurodegener Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Beta-N-Acetil-Hexosaminidases / Proteínas tau / Tauopatias Limite: Animals Idioma: En Revista: Mol Neurodegener Ano de publicação: 2017 Tipo de documento: Article