Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing.

Cheng, Donavan T; Prasad, Meera; Chekaluk, Yvonne; Benayed, Ryma; Sadowska, Justyna; Zehir, Ahmet; Syed, Aijazuddin; Wang, Yan Elsa; Somar, Joshua; Li, Yirong; Yelskaya, Zarina; Wong, Donna; Robson, Mark E; Offit, Kenneth; Berger, Michael F; Nafa, Khedoudja; Ladanyi, Marc; Zhang, Liying

Cheng, Donavan T; Prasad, Meera; Chekaluk, Yvonne; Benayed, Ryma; Sadowska, Justyna; Zehir, Ahmet; Syed, Aijazuddin; Wang, Yan Elsa; Somar, Joshua; Li, Yirong; Yelskaya, Zarina; Wong, Donna; Robson, Mark E; Offit, Kenneth; Berger, Michael F; Nafa, Khedoudja; Ladanyi, Marc; Zhang, Liying.

Afiliação

Cheng DT; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Prasad M; Illumina Inc, Santa Clara, CA, USA.
Chekaluk Y; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Benayed R; Brigham and Women's Hospital, Boston, MA, USA.
Sadowska J; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Zehir A; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Syed A; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Wang YE; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Somar J; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Li Y; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Yelskaya Z; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Wong D; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Robson ME; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Offit K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Berger MF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nafa K; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.
Ladanyi M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zhang L; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.

BMC Med Genomics ; 10(1): 33, 2017 05 19.

Article em En | MEDLINE | ID: mdl-28526081

Assuntos

Análise Mutacional de DNA/métodos; Predisposição Genética para Doença; Mutação em Linhagem Germinativa; Proteínas de Neoplasias/genética; Neoplasias/metabolismo; Proteína da Polipose Adenomatosa do Colo/genética; Proteínas Mutadas de Ataxia Telangiectasia/genética; Proteína BRCA1/genética; Proteína BRCA2/genética; Biomarcadores Tumorais/genética; Quinase do Ponto de Checagem 2/genética; Variações do Número de Cópias de DNA; Humanos; Neoplasias/genética; Polimorfismo de Nucleotídeo Único; Reprodutibilidade dos Testes; Proteína 2 do Complexo Esclerose Tuberosa; Proteína Supressora de Tumor p53/genética; Proteínas Supressoras de Tumor/genética; Proteína Supressora de Tumor Von Hippel-Lindau/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Mutacional de DNA / Mutação em Linhagem Germinativa / Predisposição Genética para Doença / Proteínas de Neoplasias / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: BMC Med Genomics Ano de publicação: 2017 Tipo de documento: Article

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