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[The effects of heptaminol chlorhydrate on neuromuscular transmission]. / Effets du chlorhydrate d'heptaminol sur la transmission neuromusculaire.
Vautrin, J; Mambrini, J; Mauro, N; Quillent, C.
Afiliação
  • Vautrin J; Laboratoire de physiologie générale, Université Paris XII, Créteil, France.
Can J Physiol Pharmacol ; 66(11): 1442-9, 1988 Nov.
Article em Fr | MEDLINE | ID: mdl-2853994
6-Amino-2-methyl-2-heptanol chlorhydrate, heptaminol chlorhydrate, blocks the response to indirect stimulation of the mouse diaphragm in vitro. This effect is due to a dose-dependent pre- and post-synaptic block of neuromuscular transmission starting at 1 mM heptaminol (HEPT). The complete block of neuromuscular transmission occurs at 10 mM. At 2 mM, the decrease in quantal size is more significant in the presence of d-tubocurarine than when the extracellular calcium is lowered. At this concentration, heptaminol also prolongs the depolarization time of the motor end plate potential. Slightly higher concentrations of heptaminol produce a decrease in quantal content. This latter effect is associated with an increase in synaptic delay.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amino Álcoois / Heptaminol / Junção Neuromuscular Limite: Animals Idioma: Fr Revista: Can J Physiol Pharmacol Ano de publicação: 1988 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amino Álcoois / Heptaminol / Junção Neuromuscular Limite: Animals Idioma: Fr Revista: Can J Physiol Pharmacol Ano de publicação: 1988 Tipo de documento: Article