Characterization of hormonal profiles during the luteal phase in regularly menstruating women.
Fertil Steril
; 108(1): 175-182.e1, 2017 07.
Article
em En
| MEDLINE
| ID: mdl-28579410
ABSTRACT
OBJECTIVE:
To characterize the variability of hormonal profiles during the luteal phase in normal cycles.DESIGN:
Observational study.SETTING:
Not applicable. PATIENT(S) Ninety-nine women contributing 266 menstrual cycles. INTERVENTION(S) The women collected first morning urine samples that were analyzed for estrone-3-glucuronide, pregnanediol-3-alpha-glucuronide (PDG), FSH, and LH. The women had serum P tests (twice per cycle) and underwent ultrasonography to identify the day of ovulation. MAIN OUTCOME MEASURE(S) The luteal phase was divided into three parts the early luteal phase with increasing PDG (luteinization), the midluteal phase with PDG ≥10 µg/mg Cr (progestation), and the late luteal phase (luteolysis) when PDG fell below 10 µg/mg Cr. RESULT(S) Long luteal phases begin with long luteinization processes. The early luteal phase is marked by low PDG and high LH levels. Long luteinization phases were correlated with low E1G and low PDG levels at day 3. The length of the early luteal phase is highly variable between cycles of the same woman. The duration and hormonal levels during the rest of the luteal phase were less correlated with other characteristics of the cycle. CONCLUSION(S) The study showed the presence of a prolonged pituitary activity during the luteinization process, which seems to be modulated by an interaction between P and LH. This supports a luteal phase model with three distinct processes the first is a modulated luteinization process, whereas the second and the third are relatively less modulated processes of progestation and luteolysis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios
/
Fase Luteal
/
Menstruação
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2017
Tipo de documento:
Article