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Evaluation of the efficacy and toxicity profile associated with intraperitoneal chemotherapy use in older women.
Crim, A; Rowland, M; Ruskin, R; Dvorak, J; Greenwade, M; Walter, A; Gillen, J; Ding, K; Moore, K; Gunderson, C.
Afiliação
  • Crim A; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: aleia-crim@ouhsc.edu.
  • Rowland M; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Michelle-Rowland@ouhsc.edu.
  • Ruskin R; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Rachel-Ruskin@ouhsc.edu.
  • Dvorak J; Department of Biostatistics and Epidemiology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Justin-Dvorak@ouhsc.edu.
  • Greenwade M; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Molly-Greenwade@ouhsc.edu.
  • Walter A; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Adam-Walter@ouhsc.edu.
  • Gillen J; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Jessica-Gillen@ouhsc.edu.
  • Ding K; Department of Biostatistics and Epidemiology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Kai-Ding@ouhsc.edu.
  • Moore K; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Kathleen-Moore@ouhsc.edu.
  • Gunderson C; Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK, USA. Electronic address: Camille-Gunderson@ouhsc.edu.
Gynecol Oncol ; 146(2): 268-272, 2017 08.
Article em En | MEDLINE | ID: mdl-28583323
OBJECTIVE: Intraperitoneal (IP) chemotherapy (CT) for treatment of epithelial ovarian cancer (EOC) has been shown to provide a substantial OS advantage. This study aims to compare the toxicity and benefits of IP CT in patients ≥70 with those <70. METHODS: We performed a single institution retrospective review of patients diagnosed with Stage IIA-IIIC EOC from 2000 to 2013 who received IP CT. Clinicopathologic characteristics were extracted, and survival was calculated. RESULTS: 133 patients were included with 100 pts. <70years old and 33 pts. ≥70years old. Clinical trial enrollment was similar despite age. In trial enrolled patients, older patients received statistically fewer cycles of therapy (6.4 vs 5.8, p=0.002) but had similar dose delays (0.9 vs 0.7, p=0.72), and modifications (0.9 vs 0.36, p=0.11). Median PFS (27 vs 31months) and OS (71 and 62months) were not statistically different. Grade 3/4 neutropenia was significantly worse in the older patients (82% vs 100%, p=0.04). Neuropathy grade ≥2 and other non-hematologic toxicities were not different between age groups. CONCLUSIONS: Despite completing fewer cycles of IP CT, older EOC patients had comparable survival to younger patients. The population of older patients receiving IP CT in this study were on clinical trial and likely to be heartier than the general older population. IP CT appears well tolerated and effective among select older patients and is likely under-utilized outside of clinical trials.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Císticas, Mucinosas e Serosas / Carcinoma Endometrioide / Adenocarcinoma de Células Claras / Neoplasias Epiteliais e Glandulares / Procedimentos Cirúrgicos de Citorredução Tipo de estudo: Observational_studies Limite: Aged / Female / Humans Idioma: En Revista: Gynecol Oncol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Císticas, Mucinosas e Serosas / Carcinoma Endometrioide / Adenocarcinoma de Células Claras / Neoplasias Epiteliais e Glandulares / Procedimentos Cirúrgicos de Citorredução Tipo de estudo: Observational_studies Limite: Aged / Female / Humans Idioma: En Revista: Gynecol Oncol Ano de publicação: 2017 Tipo de documento: Article