Tryptophan/copper-catalyzed aromatization reaction of chiral cyclohexanones to phenols.
Org Biomol Chem
; 15(24): 5126-5130, 2017 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-28594034
ABSTRACT
By merging organocatalysis with copper catalysis, a highly efficient stereospecific approach for the synthesis of chiral phenols from cyclohexanones has been developed for the first time. The aromatization reaction proceeds through the in situ formation of enone intermediates and further subsequent bromination/dehydrobromination reactions. And a series of functionalized phenol derivatives are obtained in good yields (up to 89%) and good to excellent enantioselectivities (up to 99% ee).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2017
Tipo de documento:
Article