Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening.

Christensen, Anne G; Ehmsen, Sidse; Terp, Mikkel G; Batra, Richa; Alcaraz, Nicolas; Baumbach, Jan; Noer, Julie B; Moreira, José; Leth-Larsen, Rikke; Larsen, Martin R; Ditzel, Henrik J

Christensen, Anne G; Ehmsen, Sidse; Terp, Mikkel G; Batra, Richa; Alcaraz, Nicolas; Baumbach, Jan; Noer, Julie B; Moreira, José; Leth-Larsen, Rikke; Larsen, Martin R; Ditzel, Henrik J.

Afiliação

Christensen AG; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Ehmsen S; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Terp MG; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Batra R; Department of Mathematics and Computer Science, Faculty of Science, University of Southern Denmark, Odense, Denmark.
Alcaraz N; Department of Mathematics and Computer Science, Faculty of Science, University of Southern Denmark, Odense, Denmark.
Baumbach J; Department of Mathematics and Computer Science, Faculty of Science, University of Southern Denmark, Odense, Denmark.
Noer JB; Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Section for Molecular Disease Biology, University of Copenhagen, Frederiksberg C, Denmark.
Moreira J; Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Section for Molecular Disease Biology, University of Copenhagen, Frederiksberg C, Denmark.
Leth-Larsen R; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Larsen MR; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Ditzel HJ; Department of Clinical Biochemistry and Pharmacology, Centre for Clinical Proteomics, Odense University Hospital, Odense, Denmark.

Stem Cells ; 35(8): 1898-1912, 2017 08.

Article em En | MEDLINE | ID: mdl-28600813

Assuntos

Avaliação Pré-Clínica de Medicamentos; Modelos Biológicos; Células-Tronco Neoplásicas/patologia; Transdução de Sinais; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/patologia; Animais; Antígenos CD/metabolismo; Apoptose; Biomarcadores Tumorais/metabolismo; Carcinogênese/metabolismo; Carcinogênese/patologia; Linhagem Celular Tumoral; Proliferação de Células; Forma Celular; Sobrevivência Celular; Transição Epitelial-Mesenquimal; Feminino; Humanos; Espectrometria de Massas; Camundongos; Mapas de Interação de Proteínas; Proteômica; Reprodutibilidade dos Testes; Esferoides Celulares/patologia; Via de Sinalização Wnt

Palavras-chave

Apoptosis; Cancer stem cells; Mammospheres; NF-κB; Targeted treatment; Triple-negative breast cancer

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Transdução de Sinais / Avaliação Pré-Clínica de Medicamentos / Neoplasias de Mama Triplo Negativas / Modelos Biológicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Stem Cells Ano de publicação: 2017 Tipo de documento: Article

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