Your browser doesn't support javascript.
loading
Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
Nolte, Ilja M; Munoz, M Loretto; Tragante, Vinicius; Amare, Azmeraw T; Jansen, Rick; Vaez, Ahmad; von der Heyde, Benedikt; Avery, Christy L; Bis, Joshua C; Dierckx, Bram; van Dongen, Jenny; Gogarten, Stephanie M; Goyette, Philippe; Hernesniemi, Jussi; Huikari, Ville; Hwang, Shih-Jen; Jaju, Deepali; Kerr, Kathleen F; Kluttig, Alexander; Krijthe, Bouwe P; Kumar, Jitender; van der Laan, Sander W; Lyytikäinen, Leo-Pekka; Maihofer, Adam X; Minassian, Arpi; van der Most, Peter J; Müller-Nurasyid, Martina; Nivard, Michel; Salvi, Erika; Stewart, James D; Thayer, Julian F; Verweij, Niek; Wong, Andrew; Zabaneh, Delilah; Zafarmand, Mohammad H; Abdellaoui, Abdel; Albarwani, Sulayma; Albert, Christine; Alonso, Alvaro; Ashar, Foram; Auvinen, Juha; Axelsson, Tomas; Baker, Dewleen G; de Bakker, Paul I W; Barcella, Matteo; Bayoumi, Riad; Bieringa, Rob J; Boomsma, Dorret; Boucher, Gabrielle; Britton, Annie R.
Afiliação
  • Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Munoz ML; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Tragante V; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
  • Amare AT; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Jansen R; Department of Epidemiology, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia.
  • Vaez A; College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar 6000, Ethiopia.
  • von der Heyde B; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
  • Avery CL; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Bis JC; School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
  • Dierckx B; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
  • van Dongen J; Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden.
  • Gogarten SM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Goyette P; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
  • Hernesniemi J; Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Huikari V; The Generation R Study Group, Erasmus MC, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Hwang SJ; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Jaju D; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Kerr KF; Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
  • Kluttig A; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Krijthe BP; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
  • Kumar J; Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.
  • van der Laan SW; Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
  • Lyytikäinen LP; Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Maihofer AX; Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.
  • Minassian A; Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat-Al Khoudh 123, Sultanate of Oman.
  • van der Most PJ; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
  • Müller-Nurasyid M; Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06097, Germany.
  • Nivard M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
  • Salvi E; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
  • Stewart JD; Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden.
  • Thayer JF; Laboratory of Experimental Cardiology, Department of Heart and Lung, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
  • Verweij N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Wong A; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
  • Zabaneh D; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • Zafarmand MH; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA.
  • Abdellaoui A; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
  • Albarwani S; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA.
  • Albert C; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Alonso A; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Ashar F; Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.
  • Auvinen J; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany.
  • Axelsson T; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
  • Baker DG; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands.
  • de Bakker PIW; Department of Health Sciences, University of Milano, Milano 20122, Italy.
  • Barcella M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Bayoumi R; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Bieringa RJ; Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, Ohio 43210, USA.
  • Boomsma D; Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
  • Boucher G; MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK.
  • Britton AR; Institute of Psychiatry, Psychology &Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
Nat Commun ; 8: 15805, 2017 06 14.
Article em En | MEDLINE | ID: mdl-28613276
ABSTRACT
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74blood pressure (-0.35biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Cardiopatias / Frequência Cardíaca Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Nat Commun Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Cardiopatias / Frequência Cardíaca Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Nat Commun Ano de publicação: 2017 Tipo de documento: Article