Quantifying forces in cell biology.
Nat Cell Biol
; 19(7): 742-751, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28628082
ABSTRACT
Cells exert, sense, and respond to physical forces through an astounding diversity of mechanisms. Here we review recently developed tools to quantify the forces generated by cells. We first review technologies based on sensors of known or assumed mechanical properties, and discuss their applicability and limitations. We then proceed to draw an analogy between these human-made sensors and force sensing in the cell. As mechanics is increasingly revealed to play a fundamental role in cell function we envisage that tools to quantify physical forces may soon become widely applied in life-sciences laboratories.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
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Técnicas Biossensoriais
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Membrana Celular
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Biologia Celular
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Mecanotransdução Celular
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Microscopia
Limite:
Animals
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Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2017
Tipo de documento:
Article