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T cells from patients with Parkinson's disease recognize α-synuclein peptides.
Sulzer, David; Alcalay, Roy N; Garretti, Francesca; Cote, Lucien; Kanter, Ellen; Agin-Liebes, Julian; Liong, Christopher; McMurtrey, Curtis; Hildebrand, William H; Mao, Xiaobo; Dawson, Valina L; Dawson, Ted M; Oseroff, Carla; Pham, John; Sidney, John; Dillon, Myles B; Carpenter, Chelsea; Weiskopf, Daniela; Phillips, Elizabeth; Mallal, Simon; Peters, Bjoern; Frazier, April; Lindestam Arlehamn, Cecilia S; Sette, Alessandro.
Afiliação
  • Sulzer D; Departments of Psychiatry, Columbia University, Division of Molcular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, USA.
  • Alcalay RN; Department of Neurology, Columbia University, New York, New York 10032, USA.
  • Garretti F; Department of Pharmacology, Columbia University, New York, New York 10032, USA.
  • Cote L; Department of Neurology, Columbia University, New York, New York 10032, USA.
  • Kanter E; Departments of Psychiatry, Columbia University, Division of Molcular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, USA.
  • Agin-Liebes J; Department of Neurology, Columbia University, New York, New York 10032, USA.
  • Liong C; Departments of Psychiatry, Columbia University, Division of Molcular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, USA.
  • McMurtrey C; Departments of Psychiatry, Columbia University, Division of Molcular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, USA.
  • Hildebrand WH; Department of Neurology, Columbia University, New York, New York 10032, USA.
  • Mao X; Department of Microbiology and Immunology, University of Oklahoma, Oklahoma City, Oklahoma 73104, USA.
  • Dawson VL; Department of Microbiology and Immunology, University of Oklahoma, Oklahoma City, Oklahoma 73104, USA.
  • Dawson TM; Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Oseroff C; Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685, USA.
  • Pham J; Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Sidney J; Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685, USA.
  • Dillon MB; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Carpenter C; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Weiskopf D; Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Phillips E; Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685, USA.
  • Mallal S; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Peters B; Department of Pharmacology &Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Frazier A; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.
  • Lindestam Arlehamn CS; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.
  • Sette A; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.
Nature ; 546(7660): 656-661, 2017 06 29.
Article em En | MEDLINE | ID: mdl-28636593
ABSTRACT
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Linfócitos T / Alfa-Sinucleína Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Linfócitos T / Alfa-Sinucleína Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article