Evolutionary dynamics and significance of multiple subclonal mutations in cancer.

Beckman, Robert A; Loeb, Lawrence A

Beckman, Robert A; Loeb, Lawrence A.

Afiliação

Beckman RA; Departments of Oncology and Biostatistics, Bioinformatics, & Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC 20007 USA.
Loeb LA; Joseph Gottstein Memorial Cancer Research Laboratory, Departments of Pathology and Biochemistry, University of Washington School of Medicine, Seattle, WA, 98195 USA. Electronic address: laaloeb@gmail.com.

DNA Repair (Amst) ; 56: 7-15, 2017 08.

Article em En | MEDLINE | ID: mdl-28652129

Assuntos

Carcinogênese; Modelos Biológicos; Mutação; Neoplasias/genética; Reparo do DNA; Replicação do DNA; DNA de Neoplasias/metabolismo; Humanos; Neoplasias/patologia

Palavras-chave

Cancer; Carcinogenesis; DNA repair; DNA replication; Duplex sequencing; Evolutionary dynamics; Mathematical models; Mutator hypothesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinogênese / Modelos Biológicos / Mutação / Neoplasias Limite: Humans Idioma: En Revista: DNA Repair (Amst) Ano de publicação: 2017 Tipo de documento: Article

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