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Role of Microbial Agents in Pulmonary Fibrosis
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Chioma, Ozioma S; Drake, Wonder P.
Afiliação
  • Chioma OS; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
  • Drake WP; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Yale J Biol Med ; 90(2): 219-227, 2017 06.
Article em En | MEDLINE | ID: mdl-28656009
Pulmonary fibrosis is a form of lung disease that develops due to aberrant wound-healing following repeated alveoli injury in genetically susceptible individuals, resulting in chronic inflammation, excess deposition of the extracellular matrix components, mainly collagen, and scarring of lung tissue. In addition to irradiation, environmental agents such occupational inhalants, and chemotherapeutic agents, microbial agents also play a role in the etiology of the disease. While viruses have received the most attention, emerging evidence suggest that bacteria and fungi also play a part in the etiology of pulmonary fibrosis. Furthermore, successful use of antibiotics, antiviral and antifungal drugs in several studies to attenuate fibrosis progression is also an indication of microbial involvement in the pathogenesis of the disease and could be a promising therapeutic modality for treating pulmonary fibrosis initiated or exacerbated by infectious agents.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Limite: Animals / Humans Idioma: En Revista: Yale J Biol Med Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Limite: Animals / Humans Idioma: En Revista: Yale J Biol Med Ano de publicação: 2017 Tipo de documento: Article