Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents.
J Enzyme Inhib Med Chem
; 32(1): 878-884, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28661186
ABSTRACT
Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
/
Mycobacterium
/
Antituberculosos
Idioma:
En
Revista:
J Enzyme Inhib Med Chem
Ano de publicação:
2017
Tipo de documento:
Article