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Efficacy and safety of eltrombopag in persistent and newly diagnosed ITP in clinical practice.
González-López, Tomás José; Fernández-Fuertes, Fernando; Hernández-Rivas, José Angel; Sánchez-González, Blanca; Martínez-Robles, Violeta; Alvarez-Román, María Teresa; Pérez-Rus, Gloria; Pascual, Cristina; Bernat, Silvia; Arrieta-Cerdán, Esther; Aguilar, Carlos; Bárez, Abelardo; Peñarrubia, María Jesús; Olivera, Pavel; Fernández-Rodríguez, Angeles; de Cabo, Erik; García-Frade, Luis Javier; González-Porras, José Ramón.
Afiliação
  • González-López TJ; Department of Hematology, Hospital Universitario de Burgos, Avenida Islas Baleares s/n, 09006, Burgos, Spain. tjgonzalez@saludcastillayleon.es.
  • Fernández-Fuertes F; Department of Hematology, Hospital Universitario Insular de Gran Canaria, Las Palmas De Gran Canaria, Spain.
  • Hernández-Rivas JA; Department of Hematology, Hospital Infanta Leonor, Madrid, Spain.
  • Sánchez-González B; Department of Hematology, Hospital del Mar, Barcelona, Spain.
  • Martínez-Robles V; Department of Hematology, Hospital de León, León, Spain.
  • Alvarez-Román MT; Department of Hematology, Hospital Universitario La Paz, Madrid, Spain.
  • Pérez-Rus G; Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Pascual C; Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Bernat S; Department of Hematology, Hospital de La Plana, Castellón, Spain.
  • Arrieta-Cerdán E; Department of Statistics, Hospital Universitario de Burgos, Burgos, Spain.
  • Aguilar C; Department of Hematology, Hospital de Soria, Soria, Spain.
  • Bárez A; Department of Hematology, Hospital de Avila, Avila, Spain.
  • Peñarrubia MJ; Department of Hematology, Hospital Clínico de Valladolid, Valladolid, Spain.
  • Olivera P; Department of Hematology, Hospital Universitario Vall de Hebron, Barcelona, Spain.
  • Fernández-Rodríguez A; Department of Hematology, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
  • de Cabo E; Department of Hematology, Hospital del Bierzo, Ponferrada, León, Spain.
  • García-Frade LJ; Department of Hematology, Hospital Universitario Río Hortega, Valladolid, Spain.
  • González-Porras JR; Department of Hematology, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain.
Int J Hematol ; 106(4): 508-516, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28667351
Eltrombopag is safe and effective in primary chronic ITP. However, lack of clinical trials avoids a clear demonstration of its utility in newly diagnosed and persistent ITP. Our aim here is to report Spanish results for this type of patients. We retrospectively evaluated 220 adult primary ITP patients. According to standard definition, patients were allocated to newly diagnosed (n = 30), persistent (n = 30), and chronic (n = 160) ITP. Groups were homogenous regarding most relevant parameters. 180 (90%) of 220 patients achieved a platelet response (R) with 167 (75.9%) complete responses (CR) after a 15-month follow-up. No statistical significant differences among groups but a trend towards a greater efficacy in newly diagnosed ITP were observed (93.3% of responses with 86.7% of CR). Efficacy in persistent ITP (83.3% of responses with 80.0% of CR) and chronic ITP (79.4% of responses with 73.1% of CR) was similar. 70 patients (31.8%) experienced adverse events. 15 of them were grade 3-4. Most common adverse effects were headache and hepatobiliary laboratory abnormalities (HBLAs). One persistent ITP had a venous thrombosis and one chronic ITP had grade II myelofibrosis. We consider Eltrombopag use for the early stage ITP as effective and safe as it is in chronic ITP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Púrpura Trombocitopênica Idiopática / Hidrazinas Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Int J Hematol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Púrpura Trombocitopênica Idiopática / Hidrazinas Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Int J Hematol Ano de publicação: 2017 Tipo de documento: Article