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Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus.
Azizi, H; Hwang, J; Suen, V; Kang, N Z; Somvanshi, R; Tadavarty, R; Kumar, U; Sastry, B R.
Afiliação
  • Azizi H; Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada.
  • Hwang J; Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada.
  • Suen V; Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada.
  • Kang NZ; Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada.
  • Somvanshi R; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Tadavarty R; Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada.
  • Kumar U; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Sastry BR; Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Canada. Electronic address: sastry@mail.ubc.ca.
Neurosci Lett ; 655: 151-155, 2017 Aug 10.
Article em En | MEDLINE | ID: mdl-28668380
ABSTRACT
A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Privação do Sono / Serotonina / Receptor 5-HT1A de Serotonina / Região CA1 Hipocampal Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Privação do Sono / Serotonina / Receptor 5-HT1A de Serotonina / Região CA1 Hipocampal Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2017 Tipo de documento: Article