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Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer.
Miyata, Kohei; Yotsumoto, Fusanori; Fukagawa, Satoshi; Kiyoshima, Chihiro; Ouk, Nam Sung; Urushiyama, Daichi; Ito, Tomohiro; Katsuda, Takahiro; Kurakazu, Masamitsu; Araki, Ryota; Sanui, Ayako; Miyahara, Daisuke; Murata, Masaharu; Shirota, Kyoko; Yagi, Hiroshi; Takono, Tadao; Kato, Kiyoko; Yaegashi, Nobuo; Akazawa, Kohei; Kuroki, Masahide; Yasunaga, Shin'ichiro; Miyamoto, Shingo.
Afiliação
  • Miyata K; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Yotsumoto F; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Fukagawa S; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Kiyoshima C; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Ouk NS; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Urushiyama D; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Ito T; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Katsuda T; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Kurakazu M; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Araki R; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Sanui A; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Miyahara D; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Murata M; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Shirota K; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan.
  • Yagi H; Department of Gynecology and Obstetrics, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Takono T; Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan.
  • Kato K; Department of Gynecology and Obstetrics, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Yaegashi N; Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Akazawa K; Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata, Japan.
  • Kuroki M; Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
  • Yasunaga S; Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
  • Miyamoto S; Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan smiya@cis.fukuoka-u.ac.jp.
Anticancer Res ; 37(7): 3955-3960, 2017 07.
Article em En | MEDLINE | ID: mdl-28668900
ABSTRACT
Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational therapeutic target for ovarian cancer. Here, we evaluated the clinical significance of serum HB-EGF by examining the association between prognosis and serum HB-EGF levels in patients with primary ovarian cancer. We found that high serum HB-EGF concentrations were significantly associated with poor prognosis in a combined cohort of patients with all stages of ovarian cancer, as well as in a subset of patients with advanced disease. In addition, serum HB-EGF levels increased as the cancer advanced. These data suggest that serum HB-EGF may be a target for the design of novel therapies for ovarian cancer.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Fator de Crescimento Semelhante a EGF de Ligação à Heparina Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2017 Tipo de documento: Article
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Fator de Crescimento Semelhante a EGF de Ligação à Heparina Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2017 Tipo de documento: Article